glp 1 shortage update GLP-1 Pipeline Update: August 2025 - Prime Therapeutics GLP-1 Drug Shortages - Endocrinology

Some peptides are isolated from natural sources and some are made artificially

The delayed gastric emptying from GLP-1 can, however, affect the metabolism and efficacy of certain oral sedatives, as well as precipitate an increased risk of aspiration under twilight sedation

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Malkowski notes observations of individuals on GLP1 medications demonstrating gut microbiome dysbiosis, reduced diversity, reduced phyla abundance, and key bacteria